Biostealth technology for conventionally cross-linked biologic medical devices
Facta® is developed for biologic medical devices treated with conventional cross-linking and fixation methods.
Designed to preserve the structural and functional properties of bioprosthetic devices, Facta is engineered to inhibit immune-related responses. As a consequence, this reduces calcification, inflammation, and tissue degeneration over time.
Facta is designed to support long-term tissue durability and reliability across a broad range of biologic medical devices.
Plant-based ingredients
Applications
Cardiovascular devices
- Percutaneous valves
- Surgical valves
- Biologic tissue patches
Orthopedic implants
- Tendons and ligaments
- Bones
- Biomaterials (matrices, fibers)
Endovascular applications
- Vascular patches
- Dialysis fistulae
- Others
Women’s health
- Vaginal reconstruction
- Breast reconstruction
Neurology
- Intervertebral discs
- Dura mater
- Bioartificial nerves
- Others
Biologic dental implants
Benefits of Facta
- Inhibits immune system response (>log 5)
- Inhibits biofouling formation (>log 4)
- Limits calcium deposition (>log 3)
- Reduces bacterial contamination (>log 5)
- Mitigates blood clot formation
- No leaching, no delamination, no chemical degradation
- No toxic effects for patients
- Detoxification from aldehydic, epoxy, and other industrial chemical treatment residues
- Unaltered biomechanical properties
How Facta Works
By permanently capping free aldehyde groups, Facta helps reduce the risk of calcification.
Protection against the chief reasons for device failure and limited duration
Facta’s Key Advantages
1.
Prevents circulating antibodies from interacting with antigens on and inside the tissue
2.
Inhibits pathogenic microorganisms from binding and colonizing the substrate
3.
Avoids the precipitation of calcium and activation of the coagulation cascade, preventing blood clot formation