Biostealth technology for biologic medical devices, replacing current cross-linking methods and fixatives

Firmo® is developed for biologic medical devices and replaces conventional fixation methods.

Built to crosslink biologic tissues without aldehyde- or epoxy resin-based fixation, Firmo is engineered to inhibit immune-related responses. As a result, this reduces calcification, inflammation, thrombosis, infection, and tissue degeneration over time.

Firmo is designed to support long-term tissue durability and reliability across biologic medical applications, eliminating the cytotoxic effects of current sterilization and fixation methods.

Plant-based ingredients

Applications

Cardiovascular devices
  • Percutaneous valves
  • Surgical valves
  • Biologic tissue patches
  • Tendons and ligaments
  • Bones
  • Biomaterials (matrices, fibers)
  • Vascular patches
  • Dialysis fistulae
  • Others
  • Vaginal reconstruction
  • Breast reconstruction
  • Intervertebral discs
  • Dura mater
  • Bioartificial nerves
  • Others

Benefits of Firmo

Firmo is designed as an alternative to conventional cross-linking methods and fixatives for biologic devices.
  • Aldehyde-free bioprosthetic tissue, no need to wash before use
  • Inhibits immune system response (>log 5)
  • Inhibits biofouling formation (>log 4)
  • Limits calcium deposition (>log 3)
  • Reduces bacterial contamination (>log 5)
  • Mitigates blood clot formation
  • No leaching, no delamination, no chemical degradation
  • No toxic effects for patients
  • Detoxification from aldehydic, epoxy, and other industrial chemical treatment residues
  • Unaltered biomechanical properties compared with glutaraldehyde fixation

How Firmo Works

Firmo permanently bonds with biologic medical devices to create durable and biocompatible bioprosthetic tissue.

Replacing aldehyde-based fixatives, Firmo is designed to avoid cytotoxic effects and calcium salt buildup. By clearing residual cells and debris, it prevents inflammation and tissue damage while supporting long-term tissue stability.

Protecting bioprosthetic tissue from proteolytic degradation with no cytotoxic effects

Firmo's Key Advantages

1.

Forms stable, long-lasting 3D bonds without depolymerization

2.

Protects devices from bacterial adhesion, thrombosis, and calcium precipitation

3.

Neutralizes xenogeneic epitopes and ensures proper mechanical resistance

4.

Promotes endothelialization to accelerate post-implant integration

Learn more about BCI technology designed to enhance the biocompatibility of medical devices
Biostealth Technology